Carmen Brewer Ph.D. (1981, University of Maryland, Audiology and Hearing Science), CCC-A Adjunct, Department of Hearing & Speech Sciences Chief of Audiology, National Institute on Deafness and Other Communication Disorders (NIDCD) Email:       ccb2@mng.edu Phone:      301-496-5368 Address:    National Institutes of Health                  10 Center Drive, Building 10, 5C306                  Bethesda, MD 20892

Courses Taught         Research/Clinical Activities          Publications

Research/Clinical Interests

Diagnosis and identification of auditory disorders

Genetic aspects of auditory function

Otoacoustic emissions

Physiological measures of auditory and vestibular system

Auditory Processing

Courses Taught in the Past Five Years

HESP 632: Medical Audiology

HESP 701: Hearing Aids II

HESP 706: Advanced Clinical Audiology

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Research/Clinical Activities

Currently investigating and phenotyping auditory characteristics in several rare genetic disorders including Smith Magenis syndrome, McCune Albright syndrome and Fabry's disease.  These projects are multidisciplinary and involve collaboration with otolaryngology, neurology and geneticists.

Participating in several projects in which heritability of auditory processing skills is being evaluated.  One study involves an annual trip to a Twins Festival in which data is gathered on monozygotic and dizygotic twins to evaluate heritability.  Another study is investigating auditory function in a group of subjects with tune deafness.   Measures of interest include otoacoustic emissions and pitch perception.

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Recent Publications

Merideth, M., Gordon, L., Claus, S., Sachdey, V., Smith, A., Perry, M., Brewer, C., Zalewski, C., Kim, H.J., Solomon, B., Brooks, B., Gerber, L., Turner, M., Domingo, D., Hart, T., Graf, J., Reynolds, J., Gropman, A., Yanovski, J., Collins, F., Nabel, E., Cannon, R., Gahl, W., Introne, W. Hutchinson-Gilford Progeria syndrome: phenotype and course. New England Journal of Medicine, in press.

Doherty, E.S., Lachbawan, F., Hadley, D.W., Brewer, C., Zalewski, C., Kim, H.J., Solomon, B., Robenbaum, K., Domingo, D., Hart, T.C., Brooks, B., Immken, L., Lowry, R.B., Kimonis, V., Shanske, A.L., Jehee, F.S., Bueno, M.R.P., Knightley, C., McDonald-McGinn, D., Zacai, E., Muenke, M., Muenke syndrome (FGFR3) related craniosynostosis): expansion of the phenotype and review of the literature. American Journal of Medical Genetics, in press.

King, K., Makishima, T., Zalewski, C., Bakalov, V., Griffith , A, Bondy, C., Brewer, C. Analysis of Auditory Phenotype and Karyotype in 200 Females with Turner syndrome. Ear and Hearing , 28:831-841, 2007.

Jagannathan, J., Lonser, R.R., Stanger, R.A., Butman, J.A,, Vortmeyer, A.A., Zalewski, C., Brewer, C., Surowicz, C.M., Kim, H.J. Cochlear implantation for hearing loss associated with bilateral endolynphatic sac tumors in von Hippel-Lindau disease. Otology and Neurotology , 28(7): 927-930, 2007.

Jagannathan, J., Butman, J.A, Lonser, R.R., Vortmeyer, A.A., Zalewski, C., Brewer, C., Oldfield, E.H., Kim, H.J. Endolymphatic sac tumor demonstrated by intralabyrinthine hemorrhage. Case report. Journal of Neurosurgery , 107(2): 421-425, 2007.

Morell, R., Brewer, C., Dongliang, G., Snieder, H., Zalewski, C., King, K., Drayna, D., Friedman, T. A twin study of auditory processing indicates that dichotic listening ability is a strongly heritable trait. Human Genetics , 122 (1), 103-111, 2007.

Makishima, T., Madeo, A.C., Brewer, C., Zalewski, C.K., Butman, J.A., Sachdev, V., Arai, A.E., Holbrook, B.M., Rosing, D.R., Griffith, A.J. Nonsyndromic hearing loss DFNA10 and a novel mutation of EYA4: evidence for correlation of normal cardiac phenotype with truncating mutations of the Eya domain. American Journal of Medical Genetics , 143(14): 1592-8, 2007.

Vogel, D., McCarthy, P., Brandt, G., Brewer, C. The clinical audiogram: its history and current use. Communication Disorders Review , 1:81-94, 2007.

Waldman, E. and Brewer, C., Medical aspects of otologic disease. Chapter in An Essential Guide to Clinical Audiology , S. Ackley, T.N. Decker, C. Limb, editors, Lawrence Erlbaum Associates, Mahwah, NJ, 2007.

Reis, M., Kim, J., Zalewski, C., Mastrioianni, M., Moore, D., Brady, R., Schiffman, R., and Brewer, C. Neuropathic and cerebrovascular correlates of hearing loss in Fabry disease. Brain , 130:143-150, 2007.

Goldbach-Mansky, R, Dailey, N., Canna, S., Gelabert, A., Rubin, B, Kim, H., Brewer, C., Zalewski, C., et al. Neonatal onset multisystem inflammatory disease responsive to interleukin-1 b inhibition. New England Journal of Medicine , 355(6): 581-592, 2006.

Madeo, A., Pryor, S., Brewer, C., Zalewski, C., King, K., Griffith, A. Pendred syndrome. Seminars in Hearing , 2006

Pryor, S.P., Demmler, G.J., Madeo, A.C., Yang, Y., Zalewski, C.K., Brewer, C.B., Butman, J.A., Fowler, K.B., Griffith , A.J. Investigation of the role of congenital cytomegalovirus infection in the etiology of enlarged vestibular aqueducts. Archives of Otolaryngology, Head and Neck Surgery , 131: 388-392, 2005.

Kim, H. J., Butman, J., Brewer, C., Zalewski, C., Vortmeyer, A., Glenn, G., Oldfield, E., Lonser, R. Tumors of the endolymphatic sac in patients with von Hippel-Lindau disease: implications for their natural history, diagnosis and treatment. Journal of Neurosurgery , 10: 503-512, 2005

Pryor, S.P., Madeo, A.M., Reynolds, J.C., Sarlis, N.J., Arnos, K.S., Nance, W.E., Yang, Y., Zalewski, C.K., Brewer, C.C., Butman, J.A., Griffith, A.J. SLC26A/PDS genotype-phenotype correlation in hearing loss with enlargement of the vestibular aqueduct (EVA): evidence that Pendred syndrome and non-syndromic EVA are distinct clinical and genetic entities. Journal of Medical Genetics, 2004.

Makishima, T., Kurima, K., Brewer, C., Griffith , A.J. Early onset and rapid progression of dominant nonsyndromic DFNA36 hearing loss. Otology and Neurolotology . 25: 714-719, 2004.

Ness, S., Ben-Yosef, T., Bar-Lev, A., Madeo, A., Brewer, C., Avraham, K., Kornreich, R., Desnick, R., Willner, J., Friedman, T & Griffith, A. (2003). Genetic homogeneity and phenotypic variability among Ashkenazi Jews with Usher syndrome type III. J. Med Genet, 40, 76-772.

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