Hearing and Speech Sciences

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William Gaillard

M.D. (1985, Yale University School of Medicine)

Adjunct,
Department of Hearing & Speech Sciences

Associate Professor, Neurology and Pediatrics
Children's National Medical Center,
The George Washington University

Email:   wgaillar@cnmc.org
Phone:  301-405-4214  (Dept. Main Office)
Room:   0100, LeFrak Hall

Publications

Original Articles

Theodore, W. H., Kelley, K., Toczek, M., Fazilat, S. & Gaillard, W. D. (in press).  Epilepsy duration, febrile seizures, and cerebral glucose metabolism. Epilepsia.

Cho, Y. W., Motamedi, G. K., Laufenberg, I., Sohn, S. I., Lim, J. G., Lee, H., Yi, S. D., Lee, J. H., Kim, D. K., Richard, Reba R., Gaillard, W. D., Theodore, W. H., Lesser, R. L. & Steinlein, O. K. (2003). A Korean kindred with familial nocturnal frontal lobe epilepsy (ADNFLE) and mental retardation.  Arch Neurol, 60, 1625-1632.

Donati, D., Fogdell-Hahn, A., Cermelli, C., Ahkyani, N., Vortmeyer, A., Heiss, J., Cogen, P., Gaillard, W. D., Theodore, W. H. & Jacobson, S. (2003). Detection of human herpes virus (HHV-6) in human brain from mesial temporal lobe epilepsy. Neurology, 61, 1406-1411.

Gaillard, W. D., Sachs, B. C., Whitnah, J. R., Ahmad, Z., Balsamo, L. M., Pettrella, J. R., Braniecki, S. H., McKinney, C. M., Hunter, K., Xu, B. & Grandin, C. B. (2003).   Developmental aspects of language processing fMRI of verbal fluency in children and adults. Human Brain Map, 18, 176-185.

Ahmad, Z., Balsamo, L., Sachs, B., Xu, B. & Gaillard, W. D. (2003). Auditory comprehension of language in young children: Neural networks identified with fMRI. Neurology, 60, 1598-1604.

Gaillard, W. D., Balsamo, L., Ibrahim, Z., Sachs, B. C. & Xu, B. (2003). fMRI identifies regional specialization of neural networks for reading in young children.  Neurology, 60, 94-99.

Hirtz, D., Berg, A., Camfield, P., Camfield, S., Crumrine, P., Gaillard, W. D. & Shinnar S. (2003). Practice parameter: Treatment of first afebrile seizure. Neurology, 60, 166-175.

Theodore, W. H., DeCarli, C., Bhatia, S., Hatta, J. & Gaillard, W. D. (2003). Total cerebral volume is reduced in patients with localization-related epilepsy and a history of complex febrile seizures. Arch Neurol, 60, 250-252.

Xu, B., Grafman, J., Gaillard, W. D., Spanaki, M., Ishii, K., Balsamo, L., Makela, M. & Theodore, W. H. (2002). Neuroimaging reveals automatic speech coding during the perception of word meaning. NeuroImage, 17, 859-870.

Gaillard, W. D., Balsamo, L., Xu, B., Grandin, C. B., Braniecki, S. H., Papero, P., Weinstein, S., Conry, J., Pearl, P. L., Sachs, B., Sato, S., Jabbari, B., Vezina, L. G., Frattali, C. & Theodore, W. H. (2002). Language dominance in partial epilepsy patients identified with an fMRI reading task. Neurology, 59, 256-265.

Balsamo, L. M., Xu, B., Grandin, C. B., Petrella, J. R., Braniecki, S. H., Elliott, T. K. & Gaillard, W. D. (2002). Left hemisphere language dominance with an auditory naming task in children: An fMRI study. Arch Neurol, 59, 1168-1174.

Gaillard, W. D., Kopylev, L., Weinstein, S. W., Conry, J. C., Pearl, P. L., Spanaki, M. V.,  Fazilat, S., Fazilat, S.,  Reeves-Tyer, P., Dubovsky, E. C., Vezina, L. G. & Theodore, W. H. (2002). Low incidence of abnormal 18 FDG-PET in children with new onset partial epilepsy: A prospective study. Neurology, 58, 717-722.

Gaillard, W. D., Pugliesse, M., Grandin, C. B., Braniecki, S. H., Kondapaneni, P., Hunter, K., Xu, B., Petrella, J. R., Balsamo, L. & Basso, G. (2001). Cortical localization of reading in normal children: A fMRI language study. Neurology, 57, 47-54.

Gaillard, W. D., Grandin, C. B. & Xu, B. (2001). Developmental aspects of pediatric fMRI: Considerations for image acquisition, analysis, and interpretation. NeuroImage, 13, 239-249.

Xu, B., Grafman, J., Gaillard, W. D., Ishi, K., Vega-Bermudes, F., Pietrini, P., Reeves-Tyer, P., DiCamillo, P. & Theodore, W. (2001). Evidence of conjoint and extended neural networks for the computation of speech codes: The neural basis of selective impairment in reading words and pseudowords. Cerebral Cortex, 11, 267-277.

Theodore, W. H., Gaillard, W. D., DeCarli, C., Bhatia, S. & Hatta, J. (2001). Hippocampal volume and glucose metabolism in temporal lobe epileptic foci. Epilepsia, 42, 130-132.

Spanaki, M. V., Kopylev, L., Liow, K., DeCarli, C., Gaillard, W. D. & Theodore, W. H. (2000). Relationship of seizure frequency to hippocampus volume in temporal lobe epilepsy. Epilepsia, 41, 1227-1229.

Spanaki, M. V., Kopylev, L., DeCarli, C., Gaillard, W. D., Liow, K.,  Fazilat, S., Fazilat, S.,  Reeves, P., Sato, S., Kufta, C. & Theodore, W. H. (2000). Postoperative changes in cerebral metabolism in temporal lobe epilepsy. Arch Neurol, 57, 1447-1452.

Bookheimer, S. Y., Zeffiro, T. A., Blaxton, T., Gaillard, W. D. & Theodore, W. (2000).  Activation of language cortex with automatic speech tasks. Neurology, 55, 1151-1157.

Schiff, S. J., Colella, D., Hughes, E., Jacyna, G. M., Hughes, E., Creekmore, J. W., Marshall, A., Bozek-Kuzmicki, M., Benke, G., Gaillard, W. D., Conry, J. & Weinstein, S. L. (2000). Brain chirps: Spectrographic signatures of epileptic seizures. Clin Neurophysiol, 111, 953-958.

Gaillard, W. D., Hertz-Pannier, L., Mott, S. H., Barnett, A. S., LeBihan, D. & Theodore, W. H. (2000). Functional anatomy of cognitive development: fMRI of verbal fluency in children and adults. Neurology, 54, 180-185.

Spanaki, M. V.,  Siegel, H., Kopylev, L., Fazilat, S., Dean, A., Liow, K., Ben, Manachem E., Gaillard, W. D. & Theodore, W. H. (1999). The effect of vigabatrin on cerebral blood flow and metabolism. Neurology, 53, 1518-1522.

Siegal, H., Kelley, K., Stertz, B., Reeves-Tyer, P., Flamini, R., Malow, B., Gaillard, W. D., Ko, D. & Theodore, W. H. (1999). The efficacy of felbamate as add-on therapy to valproic acid in the Lennox-Gastaut syndrome. Epilepsy Res, 34, 91-97.

Theodore, W. H., Bhatia, S., Hatta, J., Fazilat, S., DeCArli, C., Bookheimer, S. Y. & Gaillard, W. D. (1999). Progressive hippocampal atrophy in patients with complex partial seizures: The effect of epilepsy duration. Neurology, 52, 132-136.

Hunter, K. E., Blaxton, T. A., Bookheimer, S. Y., Figlozzi, C. F., Grandin, C. B., Gaillard, W. D. & Theodore, W. H. (1999). 15-O water positron emission tomography in language localization: A study comparing rater evaluations and computerized region of interest analysis of PET studies with the WADA test. Ann Neurol, 45, 662-665.

Bookheimer, S. Y., Zeffiro, T. A., Blaxton, T. A., Gaillard, W. D., Malow, M. & Theodore, W. H. (1998). Regional cerebral blood flow during auditory responsive naming: Evidence for cross-modality neural activation. Neuroreport, 9, 2409-2413. 

Garvey, M. A., Gaillard, W. D., Rusin, J., Weinstein, S., Conry, J. A., Winkfield, D. R. & Vezina, L. G. (1998). Emergency brain computed tomography in children with seizures: Who is most likely to benefit? J. Pediatrics, 133, 664-669.

Gropman, A. L., Gaillard, W. D., Charya, S. V. & Campbell, P. (1998). Wernicke's disease revisited in a child with specific food phobia. Lancet, 351, 1704-1705.

DeCarli, C., Hatta, J., Fazilat, S., Fazilat, S., Gaillard, W. D. & Theodore, W. H. (1998). Extratemporal atrophy in with complex partial seizures of left temporal origin. Ann Neurol, 43, 41-45.

Bookheimer, S. Y., Zeffiro, T., Blaxton, T., Malow, B., Gaillard, W. D., Sato, S., Kufta, C., Fedio, P. & Theodore, W. H. (1997). A direct comparison of PET activation and electrocortical stimulation mapping for language localization. Neurology, 48, 1056-1065.

Hertz-Pannier, L., Gaillard, W. D., Mott, S., Cuenod, C. A., Bookheimer, S., Weinstein, S., Conry, J., Papero, P. H., Schiff, S. J., LeBihan, D. & Theodore, W. H. (1997). Noninvasive assessment of language dominance in children and adolescents with functional MRI: A preliminary study. Neurology, 48, 1003-1012.

Theodore, W. H., Sato, S., Kufta, C. V., Gaillard, W. D. & Kelley, K. (1997). FDG-PET and invasive EEG: Seizure focus detection and surgical outcome. Epilepsia, 38, 81-86.

Gaillard, W. D., Zeffiro, T., Fazilat, S., DeCarli, C., Reeves, P. & Theodore, W. H. (1996). Effect of valproate on cerebral glucose metabolism and cerebral blood flow as determined by 18-FDG and O-15 water PET. Epilepsia, 37, 515-521.

Blaxton, T. A., Bookheimer, S. Y., Zeffiro, T. A., Figlozzi, C. M., Gaillard, W. D. & Theodore, W. H. (1996). Functional mapping of human memory using PET: Comparisons of conceptual and perceptual tasks. Canadian J Exp Psych, 50, 42-56.

Bookheimer, S. Y., Zeffiro, T. A., Blaxton, T., Gaillard, W. D. & Theodore, W. (1995).  Regional blood flow during object naming and word reading. Human Brain Mapping, 3, 93-106.

Gaillard, W. D.
, Fazilat, S., White, S., Malow, B., Sato, S., Reeves, P., Herscovitch, P. & Theodore, W. H. (1995). Interictal metabolism and blood flow are uncoupled in temporal lobe cortex of patients with complex partial epilepsy. Neurology, 45, 1841-1847.

Hughes, E. S., Gaillard, W. D., Jaycna, G. M. & Schiff, S. J. (1995). Feature based detection of epileptic seizures using ECoG recording and a PAM model. Proceedings of the 17th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

Gaillard, W. D., Bhatia, S., Bookheimer, S. Y., Fazilat, S., Sato, S. & Theodore, W. H. (1995). FDG-PET and volumetric MRI in the evaluation of patients with partial epilepsy. Neurology, 45, 123-126.

Gaillard, W. D., White, S., Malow, B.,  Flamini, R., Weinstein, S., Sato, S., Kufta, C., Schiff, S., Devinsky, O., Fazilat, S., Reeves, P. & Theodore, W. H. (1995). FDG-PET in children and adolescents with partial seizures: Role in epilepsy surgery evaluation.  Epilepsy Res, 20, 77-84.

Packer, R. P., Sutton, L. N., Patel, K., Duharme, A., Schiff, S., Weinstein, S. R., Gaillard, W. D., Conry, J. & Schut, L. (1994). Seizure control following tumor surgery for low-grade glioma. J Neurosurg, 80, 998-1003.

Theodore, W. H., Gaillard, W. D., Sato, S., Kufta, C. & Leiderman, D. (1994). Positron emission tomographic measurement of cerebral blood flow and temporal lobectomy.  Ann Neurol, 36, 241-244.

Theodore, W. H., Leiderman, D., Gaillard, W., Khan, I., Reeves, P. & Lloyd-Hontz, K. (1993). The effect of naloxone on cerebral blood flow in patients with complex partial seizures. Epilepsy Res, 16, 51-54.

Bhatia, S., Bookheimer, S., Gaillard, W. & Theodore, W. (1993). Measurement of whole temporal lobe and hippocampus for MR volumetry: Normative data. Neurology, 43, 2006-2010.

Leiderman, D., Balish, M., Sato, S., Kufta, C., Gaillard, W., Reeves, P. & Theodore, W. (1992). Comparison of PET measurements of cerebral blood flow and metabolism for the localization of human epileptic foci. Epilepsy Res, 14, 153-157.

Gaillard, W. D. & Carpenter, D. O. (1986). On the transmitter at the A-To-B cell in aplysia californica.  Brain Research, 373, 311-315.

Gaillard, W. D. & Carpenter, D. O. (1986). Spectra of neurotransmitter receptors and ionic responses on cerebral A and B neurons in aplysia californica. Brain Research, 373, 303-310.

Reddy, M. & Gaillard, W. D. (1981). Kinetics of calcium carbonate (calcite)-seeded crystallization: Influence of solid/solution ratio on the reaction rate constant. J Colloid Interface Science, 80, 171-178.

Book Chapters


Berl, M. M. & Gaillard, W. D. (in press). fMRI for assessing language functions in childhood epilepsy. In Progress in epilepsy research. Nova.

Gaillard, W. D. (in press). Functional MRI of language, memory and sensorimotor cortex. In J. Duncan (Ed.),  Neuroimaging clinics of North America.

Gaillard, W.D. (in press). Metabolic and functional neuroimaging. In E. Wyllie (Ed.), Principles and practice of epilepsy (4th edition). Williams & Wilkins.

Vanderver, A. & Gaillard, W. D. (in press). Lennox-gastaut syndrome. In H. Singer (Ed.), Current therapy in pediatric neurological diseases.

Theodore, W. H. & Gaillard, W. D. (2002). Neuroimaging and the progression of epilepsy. In T. Sutula & A. Pitkänen (Eds.), Progress in brain research (135, pp.305-313).

Gaillard, W. D. (2002). Applications of fMRI towards the evaluation of patients with partial epilepsy.  In R. Reisen, M. Nuwer, M. Hallet, & C. Medina (Eds.), Advances in clinical neurophysiology (pp. 341-350). Amsterdam: Elsevier Press.

Gaillard, W. D., Xu, B. & Balsamo, L. M. (2002). Neuroimaging and disorders of communication. In Disorders of language development (XXIIIth spectrum of developmental disabilities).  York Press.

Gaillard, W. D. (2001). Complex partial seizures. In R. T. Johnson, J. W. Griffin, & J. C. McArthur (Eds.), Current therapy in neurological diseases. (Vol 6). Mosby, Inc.

Gaillard, W. D. (2001). Metabolic and functional neuroimaging. In E. Wyllie (Ed.), Principles and practice of epilepsy (3rd edition). Williams & Wilkins.

Xu, B., Grafman, J., Gaillard, W. D., Ishii, K., Vega-Bermudes, F., Pietrini, P., Reeves-Tyer, P., DiCamillo, P. & Theodore, W. H. (1998). Evidence of lateralized epicenters for the computation of speech codes: Rhyming words and pseudowords. In Advances in theoretical issues and cognitive neuroscience research of the chinese language. Hong Kong.

Gaillard, W. D., Bookheimer, S. Y. & Cohen, M. (2000). The use of fMRI in neocortical epilepsy. Advances in neurology. In P. D. Williamson, A. M. Siegel, V. M. Thadani, & M. S. Gazzangia (Eds.), Neocortical epilepsy (84, pp. 391-404). Lippincott Williams & Wilkins.

Theodore, W. H. & Gaillard, W. D. (2000). PET studies in neocortical  epilepsy advances in neurology. In P. D. Williamson, A. M. Siegel, V. M. Thadani, & M. S. Gazzangia (Eds.), Neocortical epilepsy (84, pp. 435-446). New York: Lippincott Williams & Wilkins.

Gaillard, W. D. (1998). Optic neuritis & papilitis. In J. B. Orenstein, B. L. Klein, & T. A. Mayer (Eds.), Pedistat: A rapid reference tool for pediatric emergency medicine. CMC Research Inc.

Gaillard, W. D. (1998). Afebrile seizures. In J. B. Orenstein, B. L. Klein, & T. A. Mayer (Eds.), Pedistat: A rapid reference tool for pediatric emergency medicine. CMC Research Inc.

Gaillard, W. D., Bookheimer, S. Y., Hertz-Pannier, L. & Blaxton, T. (1997). The noninvasive identification of language function: Neuroimaging and rapid transcranial magnetic stimulation (8, pp. 321-335). Neurosurgical clinics of North America.

Gaillard, W. D. (1996). Neuroimaging studies of children with epilepsy. In G. R. Lyon & J. Rumsey (Eds.), Neuroimaging: A window to the neurological foundations of learning and behavior. Baltimore: PH Brookes Pub.

Gaillard, W. D. & Tennekoon, G. (1990). Tuberous sclerosis. In R. T. Johnson (Ed.), Current therapy In neurologic disease (3rd edition).

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